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- W2352445148 abstract "Objective To study the impact of HBV-DNA on the variation of peripheral blood lymphocytes chromosome centromere, to explore the causes of spontaneous abortion in pregnant women.Methods 60 women with history of spontaneous abortion were selected,according to HBV-DNA content,they were divided into 10~3～10~5(Ⅰgroup)and10~5(Ⅱgroup)groups;15 cases selected as healthy control group.The peripheral blood lymphocytes chromosome was prepared and simultaneous observation of silver staining chromosome centromere-point variation of mutation rate and analysis the relationship between HBV-DNA content.Results There were significantly different betweenⅠgroup and the control group,Ⅰgroup andⅡgroups There was significant difference, betweenⅡgroup and the control group,and the higher the viral load,the greater the mutation rate.Conclusion Peripheral blood of hepatitis B virus can cause chromosome centromere point mutation,so that the functional centromere inactivation influence the spindle wire attached to the centromere,resulted in chromosome nondisjunction.It suggest that changes in Cd hepatitis B patients may lead to abortion one of the important reasons." @default.
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- W2352445148 date "2010-01-01" @default.
- W2352445148 modified "2023-09-23" @default.
- W2352445148 title "Relationship between HBV-DNA and centromeric dots aberration of spontaneous abortion women" @default.
- W2352445148 hasPublicationYear "2010" @default.
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