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- W2352447843 abstract "Objective To explore the expressions of metrix metalloproteinase-1(MMP-1) and metrix metalloproteinase-7(MMP-7) in esophageal cancer tissue and normal tissue,and to analyze their relationship with clinicopathological features among Hazak esophageal cancer patients. Methods The expression of MMP-1 and MMP-7 in cancer tissue and normal tissue of 45 esophageal cancer patients were detected with reverse transcription-PCR(RT-PCR). Results The positive rates of MMP-1 and MMP-7 mRNA in cancer tissues were 75.56% and 73.33%,and the positive rates of MMP-1 and MMP-7 mRNA in distal normal tissues were 15.56% and 31.11%,respectively.There were significant differences in MMP-1 and MMP-5 levels between cancer tissue and corresponding distal normal tissue(P0.05).The expression of MMP-1 was related to tumor,node,metastasis(TNM) classification,while the expression of MMP-7 was correlated with lymph nodes metastasis and TNM stage(P0.05).Positive correlation was observed between the expression of MMP-1 and MMP-7(P0.05). Conclusion The expressions of MMP-1 and MMP-7 play an important role in carcinogenesis of esophageal cancer among Hazak people.The combined actions of MMP-1 and MMP-7 may promote development of esophageal cancer." @default.
- W2352447843 created "2016-06-24" @default.
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- W2352447843 date "2012-01-01" @default.
- W2352447843 modified "2023-09-23" @default.
- W2352447843 title "Expressions and correlations of MMP-1,MMP-7 with pathologic pattern in Hazak esophageal cancer patients" @default.
- W2352447843 hasPublicationYear "2012" @default.
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