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- W2352448436 abstract "OBJECTIVE:To summarize the functions of Slit2/Robo1 singnaling on invasion and migration of gliomas.METHODS: Slit2/Robo1,Gliomas,Invasion,Migration were searched as key words by NCBI from 1996-01 to 2009-12.Choice criteria: 1) the structure and functions of Slit2/Robo1.2) the expression of Slit2/Robo1 in gliomas.3) the study on migration of gliomas.According to the choice criteria,24 papers were finally decided as references.RESULTS: Slit2/Robo1 is a conserved ligand and receptor system,which has great effects on distribution,migration,axon gidance and branches of neuron cells.Though the mechanisms of its tumor-suppressive effect have not been elucidated,it has been proved that this signaling inhibits the tumor cells invision and migration by inactivation of Cdc42-GTP.CONCLUSION: As the molecular mechanisms how Slit2/Robo1 regulates the invasion and migration are fully elucidated,the signal system will be a new taget for the prevention and treatment in gliomas." @default.
- W2352448436 created "2016-06-24" @default.
- W2352448436 creator A5030644488 @default.
- W2352448436 date "2010-01-01" @default.
- W2352448436 modified "2023-09-24" @default.
- W2352448436 title "Slit2/Robo1 signaling and gliomas infiltration" @default.
- W2352448436 hasPublicationYear "2010" @default.
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