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- W2352451739 abstract "Objective To observe the changes of coagulation mechanism in the early-phase of infections and the pathological changes in lipopolysaccharides(LPS) mice, and to explore the protective role of early application of heparin.Methods Male Balb/c mice were injected LPS or LPS with heparin,the rectal temperature, white blood cell(WBC)and platelet(PLT), plasminogen (PLG)and antithrombin-Ⅲ(AT-Ⅲ)activity were determined for all groups ; after the mice were killed, lungs, livers and spleens of mie were removed for pathological observation.Results 1.There was no significant difference in PLT among the 3 groups (P0.05). The rectal temperature, WBC, PLG and AT-Ⅲ in group B were significantly lower (P0.05) than those in the control group at the same point of time. 2. In group C, PLG was significantly higher than group B at the same point of time (P0.05). In group C_1, (AT-Ⅲ) was significantly higher than group B_1 (P0.05). 3. The pathological changes: spotted bleeding could be seen on the surface of the lungs, the liver and the spleen in group B, and under the electron microscope many inflammatory cells infiltration in group B appeared. The pathological changes of group C were slighter than those in group B at the same point of time.Conclusions In the early phase of indotoxemia, there is the consumption of coagulation and fibrinolysis, and organ damages appears.The early application of heparin may play a positive role in the treatment and protection of Pre-DIC." @default.
- W2352451739 created "2016-06-24" @default.
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- W2352451739 date "2005-01-01" @default.
- W2352451739 modified "2023-09-28" @default.
- W2352451739 title "Changes of Coagulation Mechanism in Mice with Early-Phase Endotoxemia and Effects of Heparin" @default.
- W2352451739 hasPublicationYear "2005" @default.
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