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- W2352455480 abstract "Purpose To investigate the biological characterization of three human colorectal cancer cell lines with different metastatic potentials.Methods Tumor cells were characterized in terms of their tumorogenecity,metastatic potential,in vitro growth,clonality,adhesive,mobility and invasiveness.Results After orthotopic implantation of tumor cells into the colon of nude mouse for 28 days,local,regional,and distant metastases were detected in the mice inoculated with SW480 cells,however the mice inoculated with SW480/M5 cells only had hepatic metastasis and the mice inoculated with SW620 cells only had lymphatic metastasis.SW480/M5 and SW620 cells showed greater clonality,reproductive activity,and weaker adhesion to fibronectin than SW480 cells.Conclusions Compared with SW480 cells,SW620 and SW480/M5 cells exhibit preferring to grow in certain organs in a way that cannot be explained by circulatory patterns alone.These three cell lines have the same genetic background.As such,they may represent a valuable resource for examining genetic changes late in colon cancer progression." @default.
- W2352455480 created "2016-06-24" @default.
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- W2352455480 date "2008-01-01" @default.
- W2352455480 modified "2023-09-23" @default.
- W2352455480 title "Characterization of human colorectal cancer cell lines with different metastatic potentials" @default.
- W2352455480 hasPublicationYear "2008" @default.
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