Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352458004> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2352458004 abstract "To study the effect of the cag Ⅱ of H. pylofi on the transcription of IL-8 and to explore the mechanisms of signal transduetion in the transcription of IL-8 induced by H. pylofi in gastric epithelial cells. Methods The constructed L5F11 cells were eocultured with different isogenic mutants of H. pylori and the transcription and translation of lL-8 were indicated by the luciferase activity and IL-8 rotein respectively. Results-The ability to induce the luciferase and IL-8 protein by the mutant strains were much lower than that of by parent strain 26695 (0.13±0.01vs 0.59±0.05×10~6 cpm, P0.01;0.73±0.13 vs 2.22±0.65 ng/ml,PO.05;respectively). Exposure of LSFll ceils to herbimycin A reduced both H. pylofi-induced luciferase activity(0.71±0.18 vs 1.51±0.23 x 10~6 cpm, P0.05)and IL-Sprotein production (0.83±0.41 vs 3.22±0.59 ng/ml, P0.05) but in had no effect on TNFα-induced IL8 transcription (P0.05) and IL-8 protein production ( P0.05 ). H7 inhibited TNFα-induced luciferase (0.74±0.16 vs 2.62±0.26×10~6 cpm, P0.001)and IL-8 protein production (1.45±0.38 vs 4.12±0.43 ng/ml,P0.01) but had no significant effect on H. pylori-induced luciferase activity (P0.05). Conclufions-This results showed that multiple genes in the tag Ⅱ locus play an important role in transcription of IL-8 in L5F11 gastric epithelial cells and transcription IL-8 gene induced by H. pylori is mainly mediated by the protein tyrosine kinase." @default.
- W2352458004 created "2016-06-24" @default.
- W2352458004 creator A5040218828 @default.
- W2352458004 date "1999-01-01" @default.
- W2352458004 modified "2023-09-22" @default.
- W2352458004 title "The effect and mechanisms of the cag II of Helicobacter pylori on the transcription of IL-8 in gastric epithelial cells" @default.
- W2352458004 hasPublicationYear "1999" @default.
- W2352458004 type Work @default.
- W2352458004 sameAs 2352458004 @default.
- W2352458004 citedByCount "0" @default.
- W2352458004 crossrefType "journal-article" @default.
- W2352458004 hasAuthorship W2352458004A5040218828 @default.
- W2352458004 hasConcept C104317684 @default.
- W2352458004 hasConcept C111335760 @default.
- W2352458004 hasConcept C138885662 @default.
- W2352458004 hasConcept C143065580 @default.
- W2352458004 hasConcept C153911025 @default.
- W2352458004 hasConcept C179926584 @default.
- W2352458004 hasConcept C185592680 @default.
- W2352458004 hasConcept C203014093 @default.
- W2352458004 hasConcept C2776409635 @default.
- W2352458004 hasConcept C2778690821 @default.
- W2352458004 hasConcept C41895202 @default.
- W2352458004 hasConcept C54009773 @default.
- W2352458004 hasConcept C54355233 @default.
- W2352458004 hasConcept C55493867 @default.
- W2352458004 hasConcept C68324877 @default.
- W2352458004 hasConcept C86803240 @default.
- W2352458004 hasConceptScore W2352458004C104317684 @default.
- W2352458004 hasConceptScore W2352458004C111335760 @default.
- W2352458004 hasConceptScore W2352458004C138885662 @default.
- W2352458004 hasConceptScore W2352458004C143065580 @default.
- W2352458004 hasConceptScore W2352458004C153911025 @default.
- W2352458004 hasConceptScore W2352458004C179926584 @default.
- W2352458004 hasConceptScore W2352458004C185592680 @default.
- W2352458004 hasConceptScore W2352458004C203014093 @default.
- W2352458004 hasConceptScore W2352458004C2776409635 @default.
- W2352458004 hasConceptScore W2352458004C2778690821 @default.
- W2352458004 hasConceptScore W2352458004C41895202 @default.
- W2352458004 hasConceptScore W2352458004C54009773 @default.
- W2352458004 hasConceptScore W2352458004C54355233 @default.
- W2352458004 hasConceptScore W2352458004C55493867 @default.
- W2352458004 hasConceptScore W2352458004C68324877 @default.
- W2352458004 hasConceptScore W2352458004C86803240 @default.
- W2352458004 hasLocation W23524580041 @default.
- W2352458004 hasOpenAccess W2352458004 @default.
- W2352458004 hasPrimaryLocation W23524580041 @default.
- W2352458004 hasRelatedWork W130981867 @default.
- W2352458004 hasRelatedWork W1743288038 @default.
- W2352458004 hasRelatedWork W1963603360 @default.
- W2352458004 hasRelatedWork W1965255426 @default.
- W2352458004 hasRelatedWork W2021611644 @default.
- W2352458004 hasRelatedWork W2025683111 @default.
- W2352458004 hasRelatedWork W2057584200 @default.
- W2352458004 hasRelatedWork W2086052147 @default.
- W2352458004 hasRelatedWork W2144474454 @default.
- W2352458004 hasRelatedWork W2170082645 @default.
- W2352458004 hasRelatedWork W2301126315 @default.
- W2352458004 hasRelatedWork W2360251126 @default.
- W2352458004 hasRelatedWork W2362612546 @default.
- W2352458004 hasRelatedWork W2368574688 @default.
- W2352458004 hasRelatedWork W2369727889 @default.
- W2352458004 hasRelatedWork W2387235940 @default.
- W2352458004 hasRelatedWork W2625143835 @default.
- W2352458004 hasRelatedWork W3039052456 @default.
- W2352458004 hasRelatedWork W3110291755 @default.
- W2352458004 hasRelatedWork W2188486114 @default.
- W2352458004 isParatext "false" @default.
- W2352458004 isRetracted "false" @default.
- W2352458004 magId "2352458004" @default.
- W2352458004 workType "article" @default.