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- W2352460316 abstract "To explore the effects of human beta-defensin 2 (hBD-2) in pathologic process of cholesteatoma by observing the expression of hBD-2 and the correlation of hBD-2 and density of Langhans cells(LC) in middle ear cholesteatoma.The specimens from 21 cases of acquired middle ear cholesteatoma and 10 cases of external auditory canal skin (EACS) were examined by immunohistochemical method of hBD-2 and Langerhans cells (S-100 positive cells).In EACS, hBD-2 staining was faint while in the epithelium of cholesteatoma it was much stronger, there was significant difference between them( P < 0.01). Compared to that in EACS, the number of LC in the epithelium of cholesteatoma was increased. There was a strong correlation between elevated expression of hBD-2 and increased density of LC in the epithelium of cholesteatoma ( P < 0.05).hBD-2 may play an important role in the inflammatory status of middle ear cholesteatoma. It maybe display chemotactic activity for LIangerhans cells (LC), and thus serves to link up innate and acquired immunity." @default.
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- W2352460316 date "2005-04-01" @default.
- W2352460316 modified "2023-09-24" @default.
- W2352460316 title "[The expression and significance of human beta-defensin 2 in middle ear cholesteatoma epithelium]." @default.
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