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- W2352465368 abstract "Organ transplantation is an effective treatment to end-stage organ disease,which provides survival opportunity for the patient.However,immune rejection after transplantation has become the biggest obstacle to successful treatment,and it is the primary challenge for transplantation.HO-1 is the body′s metabolic rate-limiting enzyme of heme,the protective effect of which to organ transplantation has been widely recognized.Through the induction of HO-1 over-expression in vivo,promotion of Foxp3 gene expression,stimulating the expression of scurfin protein,increasing the number of Foxp3 + Treg in the spleen and peripheral blood,increasing CD4 +CD25 +T cells,and inhibition of CD4 +T,CD8 +T cells,inhibition of immune rejection in organ transplantation can be achieved,at the same time the graft ischemia-reperfusion injury can be reduced,cell damage can be alleviated,the survival rate of transplanted organs and patients′ quality of life can be improved,which opens up the new way for the success of organ transplantation." @default.
- W2352465368 created "2016-06-24" @default.
- W2352465368 creator A5066353712 @default.
- W2352465368 date "2013-01-01" @default.
- W2352465368 modified "2023-09-27" @default.
- W2352465368 title "HO-1 Protection to Transplanted Organs by Regulating T cell" @default.
- W2352465368 hasPublicationYear "2013" @default.
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