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- W2352489764 abstract "Objective To investigate the molecular mechanism of CCl_(4) inducing fibrosis in hepatic stellate cells.Methods The expression of Transforming growth factor-β1(TGF-β1) at mRNA and protein level were detected by RT-PCR method and Western blot analysis.The proliferation and cell cycle distribution were detected with MTT method and flow cytometry.Results After treatment by(10 mmol/L) CCL_(4) for 24 hours,the mRNA and protein expression of TGF-β1 in CCl_(4) group sharply increased.In the meantime,the proliferation of CCl_(4) group cells was markedly increased.There were less G_(0)/G_(1) phase_() cells and more G_(2)/M phase cells in CCl_(4) group than those in control group.Conclusion Suitable CCl_(4) may increase the expression of TGF-β1 and the proliferation of hepatic stellate cells,which is one of mechanisms leading to hepatic fibrosis." @default.
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- W2352489764 date "2006-01-01" @default.
- W2352489764 modified "2023-09-27" @default.
- W2352489764 title "CCl_4 promotes the proliferation and expression of TGFβ1 in rat hepatic stellate cells" @default.
- W2352489764 hasPublicationYear "2006" @default.
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