Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352489876> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2352489876 startingPage "213" @default.
- W2352489876 abstract "Purpose: To observe the effect of grape seed proanthocyanidins extract(GSPE) on skin collagen metabolism and its possible mechanism in type Ⅱ diabetic rats.Methods: In order to establish type Ⅱ diabetic rat model,male SD rats were injected with streptozotocin(STZ,0.01 mol/L,30 mg/kg) after being fed high-fat diet for 4 weeks.Then the diabetic rats were randomly divided into diabetes-vehicle group(DM control group) and three GSPE treatment groups.Rats fed normal diet were randomly divided into normal and GSPE control group.The dose of GSPE control group was 250 mg/(kg.d),and the doses of three GSPE treatment groups were 125,250,500 mg/(kg.d),respectively.After administration for 12 weeks,the body weight,fasting blood glucose(FBG),skin glucose concentration and hydroxyproline content were measured.Paraffin-embedded skin sections were stained by hematoxylin-eosin(HE) and Masson,and then examined under a microscope.The thickness of skin was measured with Image-Pro Plus 6.0.Insulin like growth factor-1(IGF-1) and collagen III in rat footpad were detected by immunohistochemical method.Results: Compared with the DM control group,FBG values were decreased but there was no significant difference in threeGSPEtreatmentgroups(P 0.05).GSPE at the high dose revealed a significant reduction in glucose concentration of skin tissues when compared with the DM control group(P 0.001).In contrast,each GSPE dose group could significantly increase skin hydroxyproline content(P 0.05).After stainingskintissuesbyHEandMasson,weobservedthatGSPEcouldinhibitthe skin to be thin in diabetic rats.Compared with the DM control group,the footpad in the GSPE high-dose group had higher IGF-1 and collagen III expression.Conclusion: GSPE has improvement effect on skin collagen metabolism of type Ⅱ diabetic rats." @default.
- W2352489876 created "2016-06-24" @default.
- W2352489876 creator A5009220945 @default.
- W2352489876 creator A5014898916 @default.
- W2352489876 creator A5059788513 @default.
- W2352489876 creator A5076952774 @default.
- W2352489876 creator A5079268989 @default.
- W2352489876 creator A5083198820 @default.
- W2352489876 creator A5084175628 @default.
- W2352489876 creator A5089667816 @default.
- W2352489876 date "2013-08-15" @default.
- W2352489876 modified "2023-09-28" @default.
- W2352489876 title "Effect of Grape Seed Proanthocyanidins Extract (GSPE) on Skin Collagen Metabolism in Type II Diabetic Rats" @default.
- W2352489876 doi "https://doi.org/10.7506/spkx1002-6630-201315044" @default.
- W2352489876 hasPublicationYear "2013" @default.
- W2352489876 type Work @default.
- W2352489876 sameAs 2352489876 @default.
- W2352489876 citedByCount "0" @default.
- W2352489876 crossrefType "journal-article" @default.
- W2352489876 hasAuthorship W2352489876A5009220945 @default.
- W2352489876 hasAuthorship W2352489876A5014898916 @default.
- W2352489876 hasAuthorship W2352489876A5059788513 @default.
- W2352489876 hasAuthorship W2352489876A5076952774 @default.
- W2352489876 hasAuthorship W2352489876A5079268989 @default.
- W2352489876 hasAuthorship W2352489876A5083198820 @default.
- W2352489876 hasAuthorship W2352489876A5084175628 @default.
- W2352489876 hasAuthorship W2352489876A5089667816 @default.
- W2352489876 hasConcept C125473707 @default.
- W2352489876 hasConcept C126322002 @default.
- W2352489876 hasConcept C134018914 @default.
- W2352489876 hasConcept C142724271 @default.
- W2352489876 hasConcept C147583825 @default.
- W2352489876 hasConcept C185592680 @default.
- W2352489876 hasConcept C204232928 @default.
- W2352489876 hasConcept C204787440 @default.
- W2352489876 hasConcept C2776971262 @default.
- W2352489876 hasConcept C2778004101 @default.
- W2352489876 hasConcept C2779280383 @default.
- W2352489876 hasConcept C2779797417 @default.
- W2352489876 hasConcept C55493867 @default.
- W2352489876 hasConcept C555293320 @default.
- W2352489876 hasConcept C70899900 @default.
- W2352489876 hasConcept C71924100 @default.
- W2352489876 hasConcept C74864618 @default.
- W2352489876 hasConcept C77784730 @default.
- W2352489876 hasConceptScore W2352489876C125473707 @default.
- W2352489876 hasConceptScore W2352489876C126322002 @default.
- W2352489876 hasConceptScore W2352489876C134018914 @default.
- W2352489876 hasConceptScore W2352489876C142724271 @default.
- W2352489876 hasConceptScore W2352489876C147583825 @default.
- W2352489876 hasConceptScore W2352489876C185592680 @default.
- W2352489876 hasConceptScore W2352489876C204232928 @default.
- W2352489876 hasConceptScore W2352489876C204787440 @default.
- W2352489876 hasConceptScore W2352489876C2776971262 @default.
- W2352489876 hasConceptScore W2352489876C2778004101 @default.
- W2352489876 hasConceptScore W2352489876C2779280383 @default.
- W2352489876 hasConceptScore W2352489876C2779797417 @default.
- W2352489876 hasConceptScore W2352489876C55493867 @default.
- W2352489876 hasConceptScore W2352489876C555293320 @default.
- W2352489876 hasConceptScore W2352489876C70899900 @default.
- W2352489876 hasConceptScore W2352489876C71924100 @default.
- W2352489876 hasConceptScore W2352489876C74864618 @default.
- W2352489876 hasConceptScore W2352489876C77784730 @default.
- W2352489876 hasIssue "15" @default.
- W2352489876 hasLocation W23524898761 @default.
- W2352489876 hasOpenAccess W2352489876 @default.
- W2352489876 hasPrimaryLocation W23524898761 @default.
- W2352489876 hasRelatedWork W2079847286 @default.
- W2352489876 hasRelatedWork W2127769288 @default.
- W2352489876 hasRelatedWork W2286732964 @default.
- W2352489876 hasRelatedWork W2357388289 @default.
- W2352489876 hasRelatedWork W2361635771 @default.
- W2352489876 hasRelatedWork W2363283463 @default.
- W2352489876 hasRelatedWork W2365608119 @default.
- W2352489876 hasRelatedWork W2368175997 @default.
- W2352489876 hasRelatedWork W2375340893 @default.
- W2352489876 hasRelatedWork W2376423053 @default.
- W2352489876 hasRelatedWork W2386299894 @default.
- W2352489876 hasRelatedWork W2387942157 @default.
- W2352489876 hasRelatedWork W2388623853 @default.
- W2352489876 hasRelatedWork W2392941743 @default.
- W2352489876 hasRelatedWork W2393412931 @default.
- W2352489876 hasRelatedWork W2939885635 @default.
- W2352489876 hasRelatedWork W3032026786 @default.
- W2352489876 hasRelatedWork W3044455759 @default.
- W2352489876 hasRelatedWork W3203151367 @default.
- W2352489876 hasRelatedWork W85368241 @default.
- W2352489876 hasVolume "34" @default.
- W2352489876 isParatext "false" @default.
- W2352489876 isRetracted "false" @default.
- W2352489876 magId "2352489876" @default.
- W2352489876 workType "article" @default.