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• W2352495063 abstract "Objective To assess the effect of basic fibroblast growth factor(bFGF) and 5-fluorouracil(5-FU) applied topically on the tendon adhesion and the healing process after the flexor tendon repair in Leghorn chickens.Methods Ninety male Leghorn chickens(weighing 3.0-3.5 kg) were randomly divided into 3 groups,with 30 chickens in each group.The flexor digitorum profundus tendons of the third right toes were transected and sutured directly.The repair site in group A was given 0.6 μL fibrin sealant(FS).In group B,the repair site was given 0.6 μL FS containing 500 ng bFGF.In group C,before the tendons were transected,they had been soaked in 5-FU solution,and then the same treatment as group B was given.Six specimens of the third toe were harvested to perform the macroscopical and histological examinations at 1,2,4,and 8 weeks,respectively,and to perform the biomechanical test at 8 weeks.Results All animals survived until the experiment was completed.All incisions healed smoothly.No rupture occurred in the reparied tendon.At 8 weeks,the adhesion degree was lighter in group C than in group B(P 0.05),but there was no significant difference in the adhesion degree between group A and groups B,C(P 0.05).At 1,2,and 4 weeks after operation,the number of fibroblast cells of group A was significantly less than that of group B(P 0.05),and the number of fibroblast cells of group C was significantly less than that of group A and group B in the tendon sheath and epitenon(P 0.05);however,it was significantly more than that of group A in the tendon parenchyma(P 0.05),and no significant difference was observed when compared with that of group B(P 0.05).At 8 weeks,no difference was found among 3 groups(P 0.05).The collagen fiber content of group A was significantly less than that of group B at 4 and 8 weeks(P 0.05).In the sheath and epitenon,the collagen fiber content of group A was significantly more than that of group C at 4 weeks(P 0.05);however,no significant difference was found between 2 groups at 8 weeks(P 0.05).The collagen fiber content of group A was significantly less than that of group C in the parenchyma at 4 and 8 weeks(P 0.05).At all time points,the collagen fiber content of group B was significantly more than that of group C in the sheath and epitenon(P 0.05),but no significant difference in the parenchyma was observed between 2 groups(P 0.05).The biomechanical tests showed that the gliding excursion of the tendon in groups A,B,and C was(3.51 ± 0.56),(2.84 ± 0.42),and(4.56 ± 0.59) mm,respectively;the work of flexion was(14.08 ± 1.85),(20.62 ± 3.52),and(10.91 ± 1.53) N.mm,respectively;and the ultimate tensile strength of the tendon was(11.26 ± 1.83),(15.02 ± 2.20),and(14.40 ± 1.57) N,respectively.There were significant differences in the gliding excursion of the tendon and the work of flexion among 3 groups(P 0.05) and in the ultimate tensile strength of the tendon between group A and groups B,C(P 0.05),but there was no significant difference in the ultimate tensile strength of the tendon between group B and group C(P 0.05).Conclusion Local single-use bFGF and 5-FU can not only effectively promote the healing of flexor tendon,but also significantly reduce tendon adhesion." @default.
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• W2352495063 date "2011-06-01" @default.
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• W2352495063 title "[Effect of local basic fibroblast growth factor and 5-fluorouracil on accelerating healing and preventing tendon adhesion after flexor tendon repair]." @default.
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