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- W2352504098 abstract "[Objective]To study the effects of trichloroethylene on DNA damage in rat hepatocytes and oxidative stress in rat liver tissue.[Methods]Male SD rats were selected,5 for each group.Trichloroethylene at the doses of 1500 and 3000 mg/kg were poured into rats' stomach through mouth,then they were killed after 48 hours.DNA damage was detected by single-cell gel electrophoresis.Contents of Reactive Oxygen Species(ROS),Malondialdehyde(MDA) and Glutathione(GSH) were also measured.[Results]Trichloroethylene at the doses of 1500 and 3000mg/kg caused DNA olive tail moment increased,DNA damage rate was 41.96% and 54.13%,respectively,which was significantly higher than that of control group(P0.01);while GSH decreased signifantly compared with control group(P0.01).[Conclusion]Trichloroethylene at the doses of 1500 and 3000mg/kg induces obvious oxidative stress in rat liver tissue and causes DNA damage in rat hepatocytes." @default.
- W2352504098 created "2016-06-24" @default.
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- W2352504098 date "2009-01-01" @default.
- W2352504098 modified "2023-09-23" @default.
- W2352504098 title "Effect of Trichloroethylene on DNA Damage and Oxidative Stress in Rat Hepatocytes" @default.
- W2352504098 hasPublicationYear "2009" @default.
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