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- W2352519672 abstract "Objective To study the mechanism of alterations of PSD-95 expression in hippocampus of vascular dementia rats.Methods The vascular dementia rat model was established by permanent、 bilateral occlusion of the common carotid arteries.The water maze test was performed to detect the ability of learning and memory of the rats and the change of the expression of NR2B in hippocampus was investigated by Western blot.Results As the ischemic time continued,the ability of learning and memory of VD rats decreased and significant(P0.01) difference was found since 4 weeks after operation,compared with the control(sham operated rats).With the ischemic time prolonging,the expression of PSD-95 presented with a curve that firstly rised and then dropped.In detail,the expression reached its peak at 2 weeks after operation(P0.01),and fell down gradually,then reduced to the minimum at 16 weeks after operation(P0.01).Conclusion The change of the expression of PSD-95 was related to the generation and development of VD rats,which means PSD-95 may be employed as a new target of VD therapy." @default.
- W2352519672 created "2016-06-24" @default.
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- W2352519672 date "2010-01-01" @default.
- W2352519672 modified "2023-09-26" @default.
- W2352519672 title "The mechanism of alterations of PSD-95 expression in hippocampus of vascular dementia rats" @default.
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