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- W2352521338 abstract "Objective To study expressions of MEK1/2,ERK1/2,JAK1/2,STAT3 and c-myc genes in esophageal cancer in the Kazak population in Xinjiang,China and to explore the regulation signaling pathways for c-myc.Methods RT-PCR was used to detect c-myc expression in esophageal cancer tissues and distal normal tissues in 52 cases.Expressions of MEK1/2,ERK1/2,JAK1/2 and STAT3 were also examined for those specimens with differentially expressed c-myc gene.Results Expression of c-myc at the mRNA level in cancer tissues was higher than normal ones(P0.05).A positive correlation in expression was observed for c-myc with ERK2 and STAT3(P0.05),but not with JAK1/2 and ERK1.A positive correlation was also observed between ERK2 and MEK1 as well as between MEK2 and STAT3(P0.05).In addition,a positive correlation was detected for ERK1 with both MEK1 and MEK2(P0.05).Conclusion The MEK/ERK2/STAT3 signaling pathway may play important roles leading to c-myc overexpression during esophageal cancer development in the Kazak population,while the JAK/STAT3 signaling pathway may not be a major pathway for c-myc activation." @default.
- W2352521338 created "2016-06-24" @default.
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- W2352521338 date "2011-01-01" @default.
- W2352521338 modified "2023-09-23" @default.
- W2352521338 title "Expression of c-myc in esophageal cancer in the Kazak population in Xinjiang, China:implications for regulatory mechanisms" @default.
- W2352521338 hasPublicationYear "2011" @default.
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