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- W2352572023 abstract "Objective:To study the clinical value of brain natriuretic peptide(BNP) assay in the diagnosis of chronic obstructive pulmonary disease(COPD) complicating with acute dyspnea. Methods:Seventy-eight COPD patients presenting with acute dyspnea were divided into 3 groups:group A contained 43 patients without heart insufficiency,group B 15 patients complicating with left heart insufficiency and group C 20 patients complicating with right heart insufficiency. The plasma BNP levels and ultrasonic cardiogram were measured and compared among the 3 groups;and the BNP cut-off value was determined by the subject performance curve. Results:The BNP level was(60. 3 ± 55. 8)pg /ml in group A,(1 489. 4 ± 1 011. 3) pg /ml in group B and(437. 9 ± 391. 3) pg /ml in group C;the difference was significant among the 3 groups( P 0. 01). Echocardiography data showed that the left ventricular inner diameter in group A and group C was significantly less than that in group B;the left ventricular ejection fraction in group A was significantly higher than that in group B and group C(P 0. 01),and the left ventricular ejection fraction in group C was significantly higher than that in group B(P 0. 01);The internal dimension of the right ventricular and the pulmonary artery pressure in group C were higher than those in group B and group A(P 0. 01);The internal dimension of the right ventricle /left ventricle in group B was significantly less than that in group A and group C(P 0. 01). The BNP cut-off value was defined as 100 pg /ml by subjects performance curve;the sensitivity of cardiac insufficiency was predicted as 83. 5%,and the specificity as 81. 5%. Conclusions:The measurement of the plasma BNP level is essential to differential diagnosis of dyspnea etiology in patients with COPD;and the BNP levels are correlated with the type of the heart insufficiency." @default.
- W2352572023 created "2016-06-24" @default.
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- W2352572023 date "2014-01-01" @default.
- W2352572023 modified "2023-09-23" @default.
- W2352572023 title "Clinical significance of brain natriuretic peptide assay in the diagnosis of chronic obstructive pulmonary disease presenting with acute dyspnea" @default.
- W2352572023 hasPublicationYear "2014" @default.
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