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- W2352572889 abstract "Objective:To invistage Th1/Th2-type cytokines production of PBMC in chronic hepatitis B virus infection patients during Lamivudine treatment. Methods: PBMC of 20 chronic hepatitis B virus infection patients were stimulated with PHA (100μg/ml)、HBcAg(1μg/ml)、HBeAg(1μg/ml) before and during the patients received Lamividine treatment at 3 months、 6 months and 9 months. INF-γ、 IL-10 production were determined by ELISA after 48 hours. Results: IFN-γ production was significantly greater at 6 months during treatment than that before Lamivudine treatment when PBMC was induced by PHA. Production of IFN-γ significantly increased and production of IL-10 significantly decreased at 9 months during Lamividine treatment campared to that before Lamivudine treatment when PBMCs were induced by PHA,HBcAg, HBeAg respectively. Conclusion: IFN-γ production of PBMC in chronic hepatitis B virus infection patients was increased and IL-10 decreased during long-time Lamivudine treatment. The dates suggested that long-time Lamivudine treatment dose not only resistant HBV but also enhance IFN-γ production and decrease IL-10 production." @default.
- W2352572889 created "2016-06-24" @default.
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- W2352572889 date "2001-01-01" @default.
- W2352572889 modified "2023-09-27" @default.
- W2352572889 title "Th_1/Th_2-type Cytokines Produced by PBMC in Chronic Hepatitis B Patients during Lamivudine Treatment" @default.
- W2352572889 hasPublicationYear "2001" @default.
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