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- W2352574269 abstract "Immunofluorescent technique wasused to establish a simple and rapid method for de-tecting aneugens both in vivo and in vitro ln binucleat-ed V79 and CHL cells, micronucleated cells containingkinetochore induced by the spindle poison colchicinewere more than 76% and 66%,while those induced bythe clastogen mytomycin Cwere less than27% and21%.In BALB/c mouse bone marrow erythrocytes,micronucleated cells containing kinetochore inducedby the spindle poison vincristine were more than 71%,those induced by the clastogen cyclophosphamide wereless than 15%.These results indicate that themicronucleus assay coupled with immunofluorescentstaining and scoring of kinetochores is an useful meth-od to distinguish micronuclei containing fragment ofchromosome induced by clastogen from micronucleicantaining whole chromosomeinduced by aneugen,sothe aneugens can be detected simply and rapidly." @default.
- W2352574269 created "2016-06-24" @default.
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- W2352574269 date "1995-01-01" @default.
- W2352574269 modified "2023-09-25" @default.
- W2352574269 title "Immunonuorescent staining method in micronucleus assay for detecting aneugens" @default.
- W2352574269 hasPublicationYear "1995" @default.
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