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- W2352590666 abstract "OBJECTIVE To investigate the expression and significance of the proto-oncogene eukaryotic initiation factor 4E (elF4E) in surgical margin of larynx and hypopharynx cancer. METHODS Twenty-five cases were evaluated: Including eighteen larynx cancers, seven hypopharynx cancers. Western blot for protein were performed in each of these cases. RESULTS The elF4E was overexpressed in the tumor core specimens (75.81 ± 20.77). In contrast, the level of elF4E expression in surgical margin were 12.90 ± 5.88, in normal tissue were 12.2 ± 5.56. All of the cases were followed up over three years. In 6 cases recurrent, 4 of them were found elF4E overexpressed in their surgical margins. CONCLUSION In this study, elF4E protein overexpression appear to be associated with malignant progression in larynx and hypopharynx cancer. It may be used as a molecular tumor marker of these tumors." @default.
- W2352590666 created "2016-06-24" @default.
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- W2352590666 date "2005-01-01" @default.
- W2352590666 modified "2023-09-23" @default.
- W2352590666 title "The expression and significantce of elF4E in lar- ynx and hypopharynx cancer surgical margins" @default.
- W2352590666 hasPublicationYear "2005" @default.
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