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- W2352596317 abstract "Objective To develop a HPLC method for determination of sucrose and lactose contents in stabilizers of biologics.Methods Test samples were precipitated with sulfosalicylic acid and centrifuged to remove the protein,and the supernatant was separated by amino column chromatography and monitored by refractive index detector(RID),based on which a correction curve was plotted by external standard method,and the developed method was verified.The sucrose and lactose contents in the final products of four kinds of vaccines were determined by the developed method.Results Both the correlation coefficients r2 of standard curves of sucrose and lactose were more than 0.999 9.Sucrose and lactose were separated completely by the developed method.The method showed high specificity for determination of sucrose and lactose.The mean recovery rates of sucrose and lactose,each at four concentrations,were 97.9% and 100.5%,while the variation coefficients were 1.28% and 0.48%,respectively.The minimum and quantitative detection limits of the developed method were 0.01 and 0.1 mg / ml respectively.The variation coefficients of detection results of sucrose and lactose contents in final products of four kinds of vaccines by the developed method were 2.59% and 1.44% respectively.Conclusion A HPLC method for determination of sucrose and lactose contents in stabilizers of biologics was developed,which was accurate and showed high reproducibility,and might be used as a routine determination method." @default.
- W2352596317 created "2016-06-24" @default.
- W2352596317 creator A5066540860 @default.
- W2352596317 date "2011-01-01" @default.
- W2352596317 modified "2023-09-23" @default.
- W2352596317 title "Determination of Sucrose and Lactose Contents in Stabilizers of Biologics by HPLC" @default.
- W2352596317 hasPublicationYear "2011" @default.
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