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- W2352609096 abstract "Objective To explore anti-tumor effect of effective components from shenetang in vivo,so as to provide experimental basis for the development of new drugs.Methods H22 tumor model in mice was built.Mice implanted with H22 were treated with effective components from shenetang for 7d,then the tumor tissues,thymus glands and spleens were weighed.The tumor inhibitory rates,immune organ index and carbon granule clearance index were calculated to investigate the anti-tumor and immune regulatory effect of effective components from shenetang in mice implanted with tumor cells.Results Effective components from shenetang showed more potent anti-tumor effect within the dose range in 8.31～70.72 g·kg-1,it could raise the decreased immune organ index and carbon granule clearance index.Conclusion Effective components from shenetang in 8.31～34.65 g·kg-1 dose range shows a certain dose-efficacy relationship of anti-tumor activity.The optimal dose of anti-tumor effect is 34.65g·kg-1 and the minimum effective dose is 8.31 g·kg-1.With the dose increasing,in a certain dose range,the inhibition enhanced,it shows dose dependency.When it achieves maximum effect,the anti-tumor effect no longer increases.The effective component can improve immune function to inhibit tumor." @default.
- W2352609096 created "2016-06-24" @default.
- W2352609096 creator A5054058694 @default.
- W2352609096 date "2013-01-01" @default.
- W2352609096 modified "2023-09-28" @default.
- W2352609096 title "Study on the Dose-efficacy Relationship of Anti-tumor in Vivo Induced by Effective Component from Shenetang" @default.
- W2352609096 hasPublicationYear "2013" @default.
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