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- W2352622195 abstract "Objective To study the relationship between apoptosis induced by etoposide in androgen independent PC 3 cells and to evaluate the expression of p53 tumor suppression gene. Methods TUNEL(TdT mediated x dUTP nick end labeling) and FCM (flow cytometry) were applied to investigate the apoptosis in PC 3 cells and distribution of cell cycle.p53 protein was detected immunohistochemically. Results Apparent apoptic morphological changes in PC 3 cells were observed by TUNEL.FCM and immunohistochemical assay indicated that the percentage of apoptic cells and the positive cells of p53 expression were increased with the increasing of exposure time and concentration of VP 16. Conclusions VP 16 can induce the programmed cell death of PC 3 cells and enhances the expression of p53 gene." @default.
- W2352622195 created "2016-06-24" @default.
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- W2352622195 date "2000-01-01" @default.
- W2352622195 modified "2023-09-22" @default.
- W2352622195 title "VP-16 induced programmed cell death and expression of p53 gene in PC 3 cells" @default.
- W2352622195 hasPublicationYear "2000" @default.
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