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- W2352645253 abstract "The synthesis of 4-methylcatechol dimethylacetate, an Calone1951 intermediate, from 4-methyl catechol and methyl bromoacetate via a Williamson condensation reaction was investigated. It was found that the addition of a suitable amount of KI as catalysts can significantly increase the product yield due to the generation of methyl iodoacetate via the reaction of KI with methyl bromoacetate. In this paper, the structure and purity of the product were firstly analyzed by using melting point measurement, IR, NMR and HPLC methods. Then the effect of the key operating factors on the product yield was investigated and the optimum operating conditions were obtained by a group of orthogonal experiments. The verification experiments demonstrate that at the optimum operating conditions: KI:C7H8O2(mol: mol) = 0.75:1; C3H5BrO2:C7H8O2(mol: mol) = 3.5:1; K2CO3:C7H8O2(mol: mol) = 4:1; reaction time = 6 h; reaction temperature=80℃, the yield of 4-methylcatechol dimethylacetate can reach 94.7% and the corresponding yield of Calone 1951 is up to 67.6%." @default.
- W2352645253 created "2016-06-24" @default.
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- W2352645253 date "2014-01-01" @default.
- W2352645253 modified "2023-09-23" @default.
- W2352645253 title "Process Study of KI Catalyzed Synthesis of 4-Methylcatechol Dimethylacetate" @default.
- W2352645253 hasPublicationYear "2014" @default.
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