Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352671625> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2352671625 abstract "In order to investigate the role and relationship between transforming growth factorbeta1(TGF-β1)and selenoprotein P in depression induced by chronic unpredictable mild stress(CUMS),the effects of intrahippocampal microinjections of TGF-β1and its receptor kinase inhibitor(LY-364947) on CUMS-induced depression and anxiety-like behaviors were investigated.The levels of depression like behaviors and related properties were measured using open-field test,tail suspension test,sucrose consumption and the body weight.The content level of TGF-β1and the selenoprotein P were detected by Elisa and Western blot respectively.The results show that compared with control group,CUMS rats showed significant depression-like behaviors,lower levels of selenoprotein P and higher levels of TGF-β1in the hippocampus.Microinjection of recombined TGF-β1didn′t result in increase of depressive-like behaviors;however,intrahippocampal injection of recombined TGF-β1can effectively reduced the depressivelike behaviors induced by CUMS.TGF-β1inhibited the expression of selenoprotein P.Interestingly,microinjection of LY-364947,the inhibitor of TGF-beta type 1receptor kinase into hippocampus also showed anti-depression effect and the expression of selenoprotein P was higher compared with CUMS/SAL group.These data suggest that selenoprotein P and TGF-β1in the hippocampus are involved in chronic stress induced depression.Selenoprotein P may play a role in the protection of hippocampus.It may be involved in the occurrence of depression in which TGF-β1inhibits the expression of selenoprotein P via TGF-beta type 1receptor.The antidepressant effects of TGF-beta1may be via other ways without the TGF-beta type 1receptor." @default.
- W2352671625 created "2016-06-24" @default.
- W2352671625 creator A5028981040 @default.
- W2352671625 date "2014-01-01" @default.
- W2352671625 modified "2023-09-26" @default.
- W2352671625 title "Involvement of transforming growth factor beta-1 and selenoprotein P in depression induced by chronic stress" @default.
- W2352671625 hasPublicationYear "2014" @default.
- W2352671625 type Work @default.
- W2352671625 sameAs 2352671625 @default.
- W2352671625 citedByCount "0" @default.
- W2352671625 crossrefType "journal-article" @default.
- W2352671625 hasAuthorship W2352671625A5028981040 @default.
- W2352671625 hasConcept C118131993 @default.
- W2352671625 hasConcept C126322002 @default.
- W2352671625 hasConcept C134018914 @default.
- W2352671625 hasConcept C136569192 @default.
- W2352671625 hasConcept C148762608 @default.
- W2352671625 hasConcept C184235292 @default.
- W2352671625 hasConcept C185592680 @default.
- W2352671625 hasConcept C2776151105 @default.
- W2352671625 hasConcept C2776841403 @default.
- W2352671625 hasConcept C2778760513 @default.
- W2352671625 hasConcept C2778979269 @default.
- W2352671625 hasConcept C2779177272 @default.
- W2352671625 hasConcept C2781001258 @default.
- W2352671625 hasConcept C2781161787 @default.
- W2352671625 hasConcept C55493867 @default.
- W2352671625 hasConcept C62525196 @default.
- W2352671625 hasConcept C71924100 @default.
- W2352671625 hasConceptScore W2352671625C118131993 @default.
- W2352671625 hasConceptScore W2352671625C126322002 @default.
- W2352671625 hasConceptScore W2352671625C134018914 @default.
- W2352671625 hasConceptScore W2352671625C136569192 @default.
- W2352671625 hasConceptScore W2352671625C148762608 @default.
- W2352671625 hasConceptScore W2352671625C184235292 @default.
- W2352671625 hasConceptScore W2352671625C185592680 @default.
- W2352671625 hasConceptScore W2352671625C2776151105 @default.
- W2352671625 hasConceptScore W2352671625C2776841403 @default.
- W2352671625 hasConceptScore W2352671625C2778760513 @default.
- W2352671625 hasConceptScore W2352671625C2778979269 @default.
- W2352671625 hasConceptScore W2352671625C2779177272 @default.
- W2352671625 hasConceptScore W2352671625C2781001258 @default.
- W2352671625 hasConceptScore W2352671625C2781161787 @default.
- W2352671625 hasConceptScore W2352671625C55493867 @default.
- W2352671625 hasConceptScore W2352671625C62525196 @default.
- W2352671625 hasConceptScore W2352671625C71924100 @default.
- W2352671625 hasLocation W23526716251 @default.
- W2352671625 hasOpenAccess W2352671625 @default.
- W2352671625 hasPrimaryLocation W23526716251 @default.
- W2352671625 hasRelatedWork W2765999349 @default.
- W2352671625 hasRelatedWork W2790668206 @default.
- W2352671625 hasRelatedWork W2800536990 @default.
- W2352671625 hasRelatedWork W2933773264 @default.
- W2352671625 hasRelatedWork W2943667280 @default.
- W2352671625 hasRelatedWork W2950169387 @default.
- W2352671625 hasRelatedWork W2974045442 @default.
- W2352671625 hasRelatedWork W2991201410 @default.
- W2352671625 hasRelatedWork W3001535797 @default.
- W2352671625 hasRelatedWork W3010944912 @default.
- W2352671625 hasRelatedWork W3013754410 @default.
- W2352671625 hasRelatedWork W3019151704 @default.
- W2352671625 hasRelatedWork W3083975618 @default.
- W2352671625 hasRelatedWork W3096868333 @default.
- W2352671625 hasRelatedWork W3099453068 @default.
- W2352671625 hasRelatedWork W3101332366 @default.
- W2352671625 hasRelatedWork W3132783290 @default.
- W2352671625 hasRelatedWork W3161896560 @default.
- W2352671625 hasRelatedWork W3183391405 @default.
- W2352671625 hasRelatedWork W3196810908 @default.
- W2352671625 isParatext "false" @default.
- W2352671625 isRetracted "false" @default.
- W2352671625 magId "2352671625" @default.
- W2352671625 workType "article" @default.