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- W2352673659 abstract "Objective To study the expression of endoplasmic reticulum stress( ERS) and autophagy-related proteins of alveolar macrophage( AM) in silicosis patients. Methods With simple random sampling,the male patients of silicosis at stage Ⅰ,Ⅱand Ⅲ were respectively chosen as the silicosis groupⅠ,Ⅱ and Ⅲ with 20,28,22 cases in each group. Six male observed subjects exposed to silica dust were selected as the control group. Bronchoalveolar lavage fluids of wholelung lavage of all subjects were collected. After AM were separated,purified cultured and lysed,the relative protein expression levels of glucose regulated protein78( GRP78),Beclin1 and microtubule-associated protein 1 light chain 3( LC3) were assayed by Western blot. Results Relative expression levels of GRP78,Beclin1 and LC3 proteins in AM of silicosis groupⅠ,Ⅱ and Ⅲ were significantly higher than those of the control group respectively( P 0. 05),the above three indicators of silicosis groupⅡ and Ⅲ were significantly higher than those of the silicosis group Ⅰ respectively( P 0. 05),and the relative expression level of GRP78 protein in AM of silicosis group Ⅲ was significantly lower than that of the silicosis groupⅡ( P 0. 05). Relative expression levels of Beclin1 and LC3 proteins in AM of silicosis group Ⅲ were higher than those of the silicosis group Ⅱ respectively,but there was no statistical significant difference( P 0. 05).Analysis results of multiple stepwise linear regression indicated that there was a positive correlation between relative expression levels of GRP78,Beclin1 and LC3 proteins respectively in AM of silicosis patients and the stage of silicosis( P 0. 01). Conclusion The related protein expression levels of ERS and autophagy in AM are different among silicosis patients at different silicotic stages. ERS and autophagy of AM may play an important role in the formation and development of silicosis." @default.
- W2352673659 created "2016-06-24" @default.
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- W2352673659 date "2015-01-01" @default.
- W2352673659 modified "2023-09-28" @default.
- W2352673659 title "Expression of endoplasmic reticulum stress and autophagy-related proteins of alveolar macrophage in patient of silicosis" @default.
- W2352673659 hasPublicationYear "2015" @default.
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