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- W2352698690 abstract "Objective To study the protective effects of different doses of L-tetrahydropalmatine(L-THP) on focal cerebral ischemia reperfusion injury in rats and its mechanism.Methods Sixty healthy SD rats were randomly divided into six groups:①sham operation,②ischemia reperfusion model(I-R),③nimodipine group(I-R+Nim10 mg·kg-1),④large dose of L-tetrahydropalmatine group (I-R+L-THP50 mg·kg-1),⑤ middle dose (I-R+L-THP25 mg·kg-1),⑥ low dose (I-R+L-THP 12.5 mg·kg-1).We used the Modifiied Longa method to make the model of focal cerebral ischemia reperfusion injury in rats,except the sham operation ones.Infarct size,hydropic volume of brain,neurological deficit scores,superoxide dismutase(SOD) activity,malondialdehyde(MDA) content in serum of rats were measured.Results The results indicated that the ischemia reperfusion injury resulted in high neurological deficit scores,large brain infact size and hydropic volume,decreased activity of SOD and increased content of MDA.It was showed that different doses of L-THP improved all signs mentioned above.Compared with the model control,L-THP I and II groups had significantly statistical meaning (P0.01),L-THP III was P0.05.Conclusion L-THP has the protective effects on rat brain damage induced by focal cerebral ischemia reperfusion,the mechanism of which might be associated with attenuating the injury by free radicals." @default.
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- W2352698690 date "2010-01-01" @default.
- W2352698690 modified "2023-09-23" @default.
- W2352698690 title "Protective Effect of L-tetrahydropalmatine on Focal Cerebral Ischemia Reperfusion Injury in Rats" @default.
- W2352698690 hasPublicationYear "2010" @default.
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