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- W2352736299 abstract "Objective To explore the role of betacyanins extracted from Portulaca oleracea L.in the therapeutic effect of cyclophosphamide(CTX) and its side-effect in mice loaded with S180 murine sarcoma cells.Methods The mice inoculated with S180 murine sarcoma cells were divided into 5 groups: S180 control group,sc 2 mg/kg·d of CTX group,ig betacyanins(250,500 and1000 mg/ kg·d) + sc CTX groups.After 10-day treatment,the tumor inhibition rate,peripheral blood cells,bone marrow karyocytes,immunoglobulin(Ig),the index of spleen and thymus,the liver and renal function were evaluated respectively.Results Although CTX application separately led to decrease of the indexes of spleen and thymus and the levels of IgG and IgM,the CTX application combined with different doses of betacyanin not only increased the tumor inhibition rate,but also improved the indexes of spleen and thymus and the levels of IgG and IgM.Similarly,the CTX in combination with different doses of betacyanin had a larger number of white blood cell(WBC),platelet(PLT) and bone marrow karyocytes than CTX group.Furthermore,betacyanin application also alleviated the CTX-induced increase of alanine aminotransferase(ALT) and blood urea nitrogen(BUN) in S180 mice.Conclusion Betacyanins extracted from Portulaca oleracea L.can enhance therapeutic effect of CTX and reduce its side-effect in the S180 mice." @default.
- W2352736299 created "2016-06-24" @default.
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- W2352736299 date "2010-01-01" @default.
- W2352736299 modified "2023-09-28" @default.
- W2352736299 title "Study on the Anti-tumor Effects of Betacyanins Extracted from Portulaca oleracea L." @default.
- W2352736299 hasPublicationYear "2010" @default.
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