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- W2352745708 abstract "Stem cells have exhibited great differentiation potentiality, which can be used in therapy for ischemia- hypoxia diseases. Ischemia is known to induce mobilization of stem cells. The tissue injury is 'sensed' by the stem cells and they migrate to the site of damage and undergo differentiation. The SDF-1/CXCR4 axis is mediator for the migration of many types of stem cells and stagnation and homing of bone marrow cells. CXCR4 stem cells migrate to the sites highly expressing SDF-1.The cells trafficking can be blocked by CXCR4(CXC chemokine receptor 4)antagonist or enhanced by overexpression of CXCR4. The aim of this review is to summarize recent studies into the role of SDF-1/CXCR4 axis in migration and tissue recovery of bone marrow stromal cells and the BMSCs based therapy for hypoxia-ischemia brain damage." @default.
- W2352745708 created "2016-06-24" @default.
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- W2352745708 date "2008-01-01" @default.
- W2352745708 modified "2023-09-22" @default.
- W2352745708 title "Research progress in effects of SDF-1/CXCR4 axis on hypoxia-ischemia brain injury" @default.
- W2352745708 hasPublicationYear "2008" @default.
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