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- W2352762139 abstract "Objective:To investigate the regulation mechanism of CXCL16after mimic ischemia/reperfusion culture of human umbilical vein endothelial cells(HUVECs)with the utilization of PDTC.Method:HUVECs were divided into 5groups:control group(culture with normal media),mimic ischemia/reperfusion group(mimic ischemic media cultured for 30min followed by normal media cultured for 4h),mimic ischemia/reperfusion group+0.1mmol/L PDTC group,mimic ischemia/reperfusion group+0.25m mol/L PDTC group and mimic ischemia/reperfusion group+0.5mmol/L PDTC group.For the latter 3groups,HUVECs were treated with PDTC1hbefore mimic ischemia/reperfusion.The inhibition efficiency of PDTC on the mRNA and protein levels of p65,the expression of CXCL16mRNA and protein as well as cell survival were determined by real-time PCR,ELISA and WST assay respectively.Result:The mRNA and protein levels of CXCL16were significantly increased by mimic ischemia/reperfusion(both P0.05).0.1,0.25and 0.5mmol/L PDTC significantly decreased mRNA levels of NF-κB and CXCL16(both P0.05).0.5mmol/L PDTC significantly suppressed supernatant CXCL16protein level(P0.05).0.1,0.25and 0.5mmol/L PDTC promoted cell survival(all P0.05).Conclusion:PDTC inhibited mimic ischemic/reperfusion-induced expression of CXCL16and promoted the survival of HUVECs." @default.
- W2352762139 created "2016-06-24" @default.
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- W2352762139 date "2014-01-01" @default.
- W2352762139 modified "2023-09-25" @default.
- W2352762139 title "Effect of PDTC on expression of CXCL16 under the condition of mimic ischemia/reperfusion in human umbilical vein endothelial cells" @default.
- W2352762139 hasPublicationYear "2014" @default.
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