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- W2352769422 abstract "Objective Clinical data of 19 Chinese patients with 21 hydroxylase deficiency (21OHD) were analyzed to improve the diagnosis and treatment level. Methods Clinical features and laboratory data were collected from 19 patients with 21OHD before and after treatment. Results In male patients, the average age of early appearance of secondary sexual character was (9.3±2.8)yrs, and excess androgen resulted in phallic enlargement. Primary amenorrhea was the most common complaint in female(87.5%), and the signs included a varying degree of labioscrotal fusion and clitoral enlargement. The average level of 17-hydroxy progesterone(17OHP) was (63.42±35.07) μg/L, and adrenocorticotrophic hormone(ACTH), dehydroepiandrosterone(sodium) sulfate(DHEAS) and testosterone(T) were obviously elevated. CT scan showed bilateral adrenal hyperplasia. The level of 17OHP was significantly decreased after treatment[(63.42±35.07) μg/L vs (3.15±2.71) μg/L](P0.01). T,DHEAS and ACTH were also decreased significantly(P0.01). Conclusion In female patients with simple virilizing form of 21OHD, primary amenorrhea was the most common complaint, and 17OHP is a good index to the diagnosis and prognosis of the disease." @default.
- W2352769422 created "2016-06-24" @default.
- W2352769422 creator A5069611208 @default.
- W2352769422 date "2006-01-01" @default.
- W2352769422 modified "2023-09-24" @default.
- W2352769422 title "Clinical Analysis of 19 Patients with 21 Hydroxylase Deficiency" @default.
- W2352769422 hasPublicationYear "2006" @default.
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