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- W2352771382 abstract "Objective To observe the effects of different doses of musk on MCP-1 expression of skull bone defect model rats and explore its mechanism of promoting exogenous rat bone mesenchymal stem cells(rBMSCs) migrate to the bone defect.Methods Adherence screening method was emplyed to cultivate BMSCs,flow cytometry to identify rBMSCs.The BMSCs were replanted after establishment of skull bone defect model in rats.Model rats were randomly divided into high-,medium-,low-dose group and blank control group,and treated with high-,medium-and low-dose of musk and normal saline respectively.After 14 days,rats were killed and removed the defect parts of skull,decalcified and sliced,and treated with immunohistochemical staining to observe under the microscope, randomly selected three horizons photographed in each slice.The resulting photos IOD was calculated with IPP6.0 processing.Results The purified rBMSCs was homogeneous fibroblast-like, adherent growth,long spindle,swirling circling arrangement.Phenotypic identification result was CD45 negative expression and CD44,CD90 positive expression.The rBMSCs differentiated to adipogenic and osteogenic after induced.Musk promoted the expression of MCP-1 at the bone defect of skull bone defect model rat,and there was significant difference between blank control group and different dose groups(P 0.01),in which the low dose was the best(P 0.05).Conclusion The mechanism of musk promoting exogenous rBMSCs migrating to injured parts is related to promoting the MCP-1 expression at the bone defect of skull bone defect model rat." @default.
- W2352771382 created "2016-06-24" @default.
- W2352771382 creator A5060059488 @default.
- W2352771382 date "2013-01-01" @default.
- W2352771382 modified "2023-09-23" @default.
- W2352771382 title "Effects of Musk on MCP-1 Expression of Skull Bone Defect Model Rats" @default.
- W2352771382 hasPublicationYear "2013" @default.
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