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- W2352771948 abstract "Objective:To study the mechanism and the effect of Ziyin Qianyang Huoxue decoction on left ventricular hypertrophy(LVH) in renovascular hypertensive rats.Methods:Sprague-Dawley rat models of renal hypertension were established with one-side renal artery clipped(2 kidneys-1 clip model).The rat models were divided into 3 groups,each group was 10 rats.The group was named as sham-operation group(C),Model group(M) and Chinese medicine group(P).C group and M group were supplied with 0.9% Nacl to inject in the abdomen 80mg·kg-1·d-1 for 8 weeks.P groups were supplied with Ziyin Qianyang Huoxue decoction 30g·kg-1·d-1 gavages for 8 weeks.The models were scrified 8 weeks later for examination of expression of AngⅡin plasma and myocardial tissue,and the mean carotid avterial pressure(mCAP),left ventricular enddiastolic pressure(LVEDP),LV±dp/dtmax and left ventricular mass/body weight ratio(LVM/BW=LVMI) were also determined in these models.Results:①The mCAP,LVEDP,LVMI and the expression of AngII in the plasma and myocardial tissue were significantly higher in M group than those in C group(P0.01).LV+dp/dtmax was lower in M group(P0.05).② LV+dp/dtmax and LV-dp/dtmax were significantly higher in P group than in M group,and mCAP,LVEDP,LVMI and the expression of AngII in the plasma and myocardial tissue were significantly lower in P group than in M group(P0.01).③The observation on electron micrographs of myocardial cell: myocardial cell ultra structrue was significantly different in the three groups.M group showed the filaments of ventricular muscles became loose,myofibril was arranged irregularly,it showed breakage and loss,widened intercalated disc,the basement membrane under the mild edema,nuclear hypnosis phenomenon was easy to see,but in P group and C group the phenomenon was significantly different.Conclusion:Ziyin Qianyang Huoxue decoction can improve the treatment of hypertension and LVH in renovascular hypertensive rats.The mechanism of anti-hypertension and reversing LVH is possibly through decreasing AngII level in plasma and myocardial tissue of the renovascular hypertensive rats,so the mechanism of Ziyin Qianyang Huoxue decoction to treat the hypertension and LVH is closely related to the rennin-angiotensin system(RAS)." @default.
- W2352771948 created "2016-06-24" @default.
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- W2352771948 date "2012-01-01" @default.
- W2352771948 modified "2023-09-25" @default.
- W2352771948 title "Effect of Ziyin Qianyang Huoxue Decoction on left Ventricular Hypertrophy in Renovascular Hypertensive rats" @default.
- W2352771948 hasPublicationYear "2012" @default.
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