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- W2352779179 abstract "Aim: The aim of this study was to explore effectual compound herbal medicine for preventing lipopolysaccharide (LPS)-induced multiple organ injury and decreasing the mortality of mice challenged with LPS. Methods: Mice were administered intragastrically with Renshen Sini decoction (RS), Huanglian Jiedu decoction (HJ), Shenfuqing decoction (SF), Shenfuqing Danshen decoction(SFD), Qingre Jiedu Liqi Huoxue decoction (QJLH) or distilled water twice a day for 3 days, two hours after Chinese herbal medicine treatment on day 3, LPS or normal saline was injected intraperitoneally, and survival rates in each group were recorded at 12-h intervals. In another experiment, mice were sacrificed at 36 h after LPS, lung, liver, kidney and small intestine were collected and processed for the HE staining. Results: At 72 h, the survival rate was 100% (n=20) in controls, but 42% in mice treated with LPS (n=26). There was no significant difference in survival rates among RS, HJ, SF group and LPS group, but survival rate in SFD group was lower than that in LPS group. Interestingly, survival in QJLH treatment group (68%, n=34) was higher than that in LPS group (26%, n=38). Histological examination revealed inflammatory organ injury in the lung and intestine, hemorrhage in the lung and kidney, degeneration, necrosis in the liver and kidney, while QJLH treatment attenuated pathological changes induced by LPS. Conclusion:These data indicated that the QJLH has a protective effect on LPS- induced multiple organ injury." @default.
- W2352779179 created "2016-06-24" @default.
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- W2352779179 date "2004-01-01" @default.
- W2352779179 modified "2023-09-25" @default.
- W2352779179 title "Effects of compound herbal decoctions on LPS-induced mortality and multiple organ injury in mice" @default.
- W2352779179 hasPublicationYear "2004" @default.
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