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- W2352780946 abstract "Objective To study the protective effects of ginkgolides on three types of cerebral ischemic models in rats.Methods Acute incomplete cerebral ischemia (AICI) model,middle cerebral artery occlusion(MCAO) model and global ischemia(GI) model were induced by different ways. With nimodipine(ND) and Yin Ke Luo(YKL) as positive controls, the effects of ginkgolides on the focal volume of cerebral infarction, indexes of hemorrheology and cerebral biochemistry, neuro behavior and the pathologic changes of brain were evaluated and analyzed. Results Ginkgolides decreased the cerebral water volume and cerebral capillary permeability in rats with AICI; it improved rats'neurotic behavior, reduced cerebral infarction volume, increased SOD activity and decreased MDA, LDH and LA levels in rats with MCAO; Ginkgolides could also reduce the blood viscosity and improve the pathological changes of ischemic brain.Conclusion Ginkgolides have protective effects on cerebral ischemia by improving cerebral ischemia and by counteracting the brain damage induced by cerebral ischemia." @default.
- W2352780946 created "2016-06-24" @default.
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- W2352780946 date "2005-01-01" @default.
- W2352780946 modified "2023-09-24" @default.
- W2352780946 title "Protective Effects of Ginkgolides on Three Types of Cerebral Ischemic Models in Rats" @default.
- W2352780946 hasPublicationYear "2005" @default.
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