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- W2352804294 abstract "Objective: To study the pharmacokinetics and tissue distribution of flomoxef (Fmox) in rabbits. Methods: Rabbits were given Fmox single intravenous injection 50 mg/kg. The concentrations of Fmox in various body fluids and tissues were determined by HPLC method. Results: The two compartment open pharmacokinetic model was in accordance with plasma concentration time curve following iv 50 mg/kg of Fmox. Fmox was quickly distributed and the half life of distribution ( t 1/2α ) was 0.023 h. The elimination half life( t 1/2β ) was 0.213 h. Aera under the plasma concentration time curve (AUC) was (79.94±13.31)h·μg/ml. The concentrations of Fmox were high in urine, bile, lung, kidney, ovary and uterus. Conclusion: Fmox is a oxacephem antibiotics with wide distribution, high tissue concentrations and short elimination half life." @default.
- W2352804294 created "2016-06-24" @default.
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- W2352804294 date "2000-01-01" @default.
- W2352804294 modified "2023-09-23" @default.
- W2352804294 title "Studies on the pharmacokinetics and tissue distribution of flomoxef in rabbits" @default.
- W2352804294 hasPublicationYear "2000" @default.
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