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- W2352804854 abstract "Objective To investigate the effects of TNF-β and the acceptor expression about mechanical renal trauma with extragenous adrenomedullin(ADM).Methods 104 healthy adult plain grade Wister rats randomly divided into four groups: 8 in the group of control,32 in the group of trauma,32 in the group injected ADM before trauma,32 in the group injected ADM post trauma.The 8 rats in the last three groups were excuted at 1 h,6 hs,12 hs and 24 hs post trauma respectively.The experimental model of rat kidney with mechanical trauma were prepared by striking the area of rat skin reflecting by kidney with free dropping ferreous hammer.ADM administrated by intrapertoneal injection at 10 min before trauma or post trauma respectively.All rats were executed by drawing-out all the blood in their hearts.Renal tissue was investigated to study positive expression of TNF-β,TNFR after SABC stained.Results The TNF-β expression of trauma group is less than it of control group in the wound early time(1 h and 6 hs).The extragenous ADM increased the expression of TNF-β(1 h and 6 hs)(P0.05).The TNFR expression of trauma group is less than it of control group in the wound early time(1 h and 6 hs).The extragenous ADM(ADM injected before trauma) increased the expression of TNFR(1h and 6hs)(P0.05).Conclusion What the TNF-β participated in renal trauma mainly is the anti-damage process.The TNFR could regulate the TNF-β in dynamic balancing.ADM increased the expression of TNF-β,TNFR at the early phase of acute trauma and supplied kidney with protection." @default.
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- W2352804854 date "2012-01-01" @default.
- W2352804854 modified "2023-09-25" @default.
- W2352804854 title "Experimentation and investigation of the effects of TNF-β and the acceptor expression in renal early trauma of rat with adrenomedullin" @default.
- W2352804854 hasPublicationYear "2012" @default.
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