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- W2352806865 abstract "Objective: The children with precocious puberty who had exposed to higher pollution of environmental endocrine disruptors (EEDs) were treated with traditional Chinese medicine (TCM). It was verified that the TCM options had antagonistic effects on proposed estrogen-like activity of EEDs. Method: A TCM treatment options made to proposed estrogen-like activity of EEDs treated 73 girls with precocious puberty, who had exposed to higher pollution of EEDs and its treatment course was three months. The volumes of uterus and ovarian, and bone mineral density were measured, and serum E2 and osteocalcin(OST) were determined before and after treatment. The animal model contaminated with 4-nonylphenol and bisphenol A were treated with the above mentioned TCM prescription for 14 days. Uterine wet weight, height of the luminal epithelium, thickness of the myometrium and the level of protein expression of proliferating cell nuclear antigen and femoral bone density of the femur in rat uterine were determined before and after treatment. All the indicators were comparatively analyzed, whose data were dealt with SPSS 11.5. Result: After treatment, the volume of uterus, serum E2 , BMC, bone density and serum OST all decreased significantly in the girls with precocious puberty (P 0.01). In the contaminated animal models with 4-nonylphenol and bisphenol A, the uterine wet weight, height of the luminal epithelium, thickness of the myometrium, levels of protein expression of PCNA and femoral bone density descended obviously (P 0.05). Conclusion: The present therapeutic regime of TCM could have the effect against the proposed estrogen-like activity of EEDs." @default.
- W2352806865 created "2016-06-24" @default.
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- W2352806865 date "2013-01-01" @default.
- W2352806865 modified "2023-09-26" @default.
- W2352806865 title "Traditional Chinese medicine has an effect against the proposed estrogen-like activity of EEDs" @default.
- W2352806865 hasPublicationYear "2013" @default.
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