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- W2352806903 abstract "Objective:To explore the relationship between corneal storage methods and rejection after corneal transplantation,and to study the roles of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor-α (TNF-α) in aqueous humor and serum in keratoplasty rejection in rats. Methods:A total of 15 Wistar rats and 30 SD rats were selected as corneal donor and recipient,respectively. Thirty eyes from 15 Wistar rats were randomly assigned to be preserved with 3 different methods (n=10 each group):moist chamber storage for 12 hours,intermediate-term storage for 7 days,and long-term storage for 12 weeks. Thirty right eyes of 30 SD rats were randomly divided into 3 groups (n=10 each group):group Ⅰ (receiving the Wistar rat cornea treated with moist chamber storage),group Ⅱ (receiving the Wistar rat cornea treated with intermediate-term storage),and group Ⅲ (receiving the Wistar rat cornea treated with long-term storage). The rejection index (RI),means survival time (MST) of corneal grafts,and histopathological changes in corneal grafts were recorded. HE and immunohistochemical staining were performed to observe the intensity of corneal rejection and the level of ICAM-1. The levels of TNF-α in the aqueous humor and serum were determined by enzyme linked immunosorbent assay after 10 days of corneal transplantation. Results:RI significantly decreased and MST was significant longer in group Ⅲ than in other 2 groups (P 0.01). The severity of corneal inflammation was less severe and the level of ICAM-1 significantly lower in group Ⅲ than in other 2 groups. Compared with groups Ⅰ and Ⅱ,the levels of TNF-α in serum and aqueous humor were significantly lower in group Ⅲ (P 0.01). Conclusion:The rejection rate after the corneal transplantation of long-term preserved cornea is lower,and the occurrence of the rejection is delayed. Both ICAM-1 and TNF-α are correlated with the corneal rejection." @default.
- W2352806903 created "2016-06-24" @default.
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- W2352806903 date "2007-01-01" @default.
- W2352806903 modified "2023-09-26" @default.
- W2352806903 title "Experimental study on the relationship between corneal storage methods and rejection after corneal transplantation" @default.
- W2352806903 hasPublicationYear "2007" @default.
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