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- W2352844373 abstract "To explore the potential efficacy and mechanism of Tα146-162 peptide pulsed imma-turemyeloid dendritic cell (Tα146-162- iMDC ) in experimental autoimmune myasthenia gravis ( EAMG ) . Methods iMDC were cultrued and pulsed with Tα146-162. EAMG mice clinically scored 1 to 2 were collected and randomly divided into treatment group and control group. Treatment group was injected subcutaneously (sc) with Tα146-162-iMDC at day 0, 7, 14 while control group received PBS at the same time. Clinical scores were evaluated before the experiment terminated at day 21. After the termination of experiment, lymphocyte proliferative response was assayed. IFN-γ, IL-6 and TGF-β in the supernatants of lymph node MNC culture were measured by ELISA. Results The difference of average clinical score between treatment group and control group was significant ( P 0.01) . Compared with control group, treatment group had a significantly reduced antigen specific lymphocyte proliferative response (P 0.01) . The production of antigen-specific IFN-γ and IL-6 in treatment group was significantly reduced ( P 0.01) . There was no difference in the production of TGF-β between control group and treatment group. Conclusion Tα146-162-iMDC can ameliorate established EAMG significantly. Tα146-162-iMDC induces immune tolerance probably by antigenic specific suppression of lymphocyte proliferation and production of IFN-γ and IL-6. TGF-β does not play an important role in the tolerance induction." @default.
- W2352844373 created "2016-06-24" @default.
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- W2352844373 date "2006-01-01" @default.
- W2352844373 modified "2023-09-25" @default.
- W2352844373 title "Efficacy of dendritic cell pulsed with Tα146-162 peptide in the treatment of experimental autoimmune myasthenia gravis" @default.
- W2352844373 hasPublicationYear "2006" @default.
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