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- W2352852017 abstract "Objective: To study oxidative stress on bronchial epithelial cells mitogen-activated protein kinase.Methods: The 1,10 umol / L of 4-hydroxynonyl(4-HNE) stimulated bronchial epithelial cells(16-HBE) were used for 0.5,2,4,8,12 hours,and immunocytochemistry was used to detect the phosphorylation of c-Jun N-terminal kinase(JNK) / stress-activated protein kinase(SAPK) and phosphorylated p38 mitogen-activated protein kinase(MAPK),phosphorylated extracellular signal regulated kinase(ERK-1) expression.Results: SAPK/JNK(Thr183 / Tyr185) and phosphorylated P38MAPK(Thr180) / Tyr182 did not change significantly.After 16-HBE cells were stimulated with 1,10μmol / L 4-HNE,phosphorylation of ERK1(P44) expression scores were 0.76 ± 0.36,0.91 ± 0.35,0.96 ± 0.36,0.99 ± 0.34 and 1.03 ± 0.36 after incubation with 1mol / L 4-HNE for 0.5,2,4,8 and 12 hours,and 0.98 ± 0.24,1.86 ± 0.20,1.69 ± 0.32,1.74 ± 0.31,1.09 ± 0.23 with stimulation with 10mol / L 4-HNE for 0.5,2,4,8 and 12 hours.Compared with the control group,the difference was statistically significant P0.05.Conclusion: The oxidative stress product 4-HNE can activate bronchial epithelial cells ERK1 / 2 pathway,resulting in cellular responses" @default.
- W2352852017 created "2016-06-24" @default.
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- W2352852017 date "2011-01-01" @default.
- W2352852017 modified "2023-09-23" @default.
- W2352852017 title "The effects of oxidative stress on mitogen-activated protein kinase signaling pathway in bronchial epithelial cells" @default.
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