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- W2352866039 abstract "Objective To observe the effect of spleen aminopeptide on peripheral blood Th1/Th2 cytokine in children with recurrent respiratory tract infection(RRTI).Methods 66 RRTI children were randomized into two groups,33 in each.The control group were given conventional anti-infection and symptomatic treatment,while the treatment group given,besides it,additional freeze-dried powder spleen aminopeptide,2 mg,oral bedtime,one time each day during acute infection period,or one time every other day after acute infection,a 3-month course.The treatment efficacy and the levels of interleukin-4(IL-4) and γ-interferon(IFN-γ) in cultured supernatant peripheral blood mononuclear cells(PBMC) were detected by double antibody sandwich ELISA before and after treatment.Results In the treatment group,IL-4 in supernatant PBMC decreased significantly(P0.01),while IFN-γ increased significantly(P0.01).In control group,there was no significant difference in IL-4 and IFN-γ levels in supernatant PBMC between pre-and post-treatments.Conclusion Spleen aminopeptide,which can enhance cell-mediated immunity induced by Th1 in RRTI children,suppress humoral immunity induced by Th2 and modulate the balance of Th1/Th2 cytokine,is an ideal drug for RRTI children with exact clinical effectiveness and good safety." @default.
- W2352866039 created "2016-06-24" @default.
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- W2352866039 date "2009-01-01" @default.
- W2352866039 modified "2023-09-23" @default.
- W2352866039 title "Effect of Spleen Aminopeptide on Th1/Th2 Cytokine in Children with Recurrent Respiratory Tract Infection" @default.
- W2352866039 hasPublicationYear "2009" @default.
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