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- W2352868758 abstract "Objective To observe the application of hypertonic sodium chloride hydroxyethyl 40 injection(HSH injection) in saving blood transfusion for acute hypervolemic hemodilution(AHH).Methods Forty patients,American Society of Anesthesiologists(ASA) classⅠorⅡ,aged 18-30,undergoing maxillary osteotomy were randomly devided into four groups: group A(AHH with HSH injection),group B(AHH with 6%HES130/0.4),group C(AHH with Multiple Electrolytes Injection) and group D(no AHH).AHH was performed within 30 mins before operation.Group A was infused with HSH injection(4 mL/kg);group B was infused with 6% HES130/0.4(15 mL/kg);group C was infused Multiple Electrolytes Injection(15 mL/kg);and group D was not given any liquid.The four groups were all routinely infused with Multiple Electrolytes Injection during operation to central venous pressure(CVP) at 4 cmH2O(1 cmH2O=0.098 kPa).The patient was given blood transfusion to achieve hematocrit(Hct)=0.25 if Hct0.25.Time points were defined as:before AHH(T1),and at the end of AHH(T2),30 minites after AHH(T3),1 hour after AHH(T4),and at the end of operation(T5).Venous blood was obtained at T1,T2,T3,T4,and T5 to measure hemoglobin(Hb) and Hct.The volume of blood transfusion,hemorrhage and urine during operation were recorded.Venous blood samples were also obtained at T1,T2,T4,and T5 to mensure Na+,K+,and Cl-levels.Results The blood losses during operation were(781.9±77.1),(748.3±65.7),(772.8±76.8),and(786.5±88.4) mL in A,B,C,and D groups,respectively(P0.05).There was no blood transfusion in group A and B,and two patients in group C and 4 in group D received blood transfusion.The urine volumes of group A and B were(420.5±51.6) and(468.1±44.3) mL,respectively,which were markedly more than that in group D([202.5±41.2] mL,P0.05).Hct and Hb in group A and B were(102.4±12.6),(99.8±9.5) g/L and 0.303±0.017,0.298±0.024,respectively,which were significantly lower than those in group D at T2([114.5±6.4] g/L and 0.341±0.024,P0.05).The expansion of blood volumes in group A and B were(23.30±2.39)% and(24.10±2.58)%,respectively,which was markedly higher than than that in group D(6.06±0.52)% at T2(P0.01).The Na+and Clˉ contents in group A at T2 were(145.8±1.6) and(112.5±2.7) mmol/L,respectively,which were significantly higher than those at T0,respectively([140.1±1.7],[99.3±2.8] mmol/L,P0.01),but they were all within the normal limit.Conclusion HSH injection(4 mL/kg) for AHH before operation has hematic protective effect.It can also provent the blood,but has no effect on electrolyte balance.(Shanghai Med J,2010,33: 143-146)" @default.
- W2352868758 created "2016-06-24" @default.
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- W2352868758 date "2010-01-01" @default.
- W2352868758 modified "2023-09-23" @default.
- W2352868758 title "Hypertonic sodium chloride hydroxyethyl 40 injection in saving blood transfusion for acute hypervolemic hemodilution" @default.
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