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- W2352885292 abstract "Objective To investigate the influence of matrine injection combined with cisplatin on the expression of apoptosis associated genes c-myc,bcl-2 and bax in human hepatocarcinoma cell line SMMC-7721.Methods Apoptotic rate was determined by TUNEL method.The expression of c-myc,bcl-2 and bax mRNA were detected by semi-quantitive RT-PCR,and the expression of c-myc,bcl-2 and bax proteins were detected by two-step immunhistochemical staining.Results The apoptotic rate was increased significantly in matrine injection,cisplatin and combined agents group respectively,compared with the control group,the difference was statistically significant(P0.05 or P0.01).The effects of combined agents were simple addition or synergistic.The apoptotic rate was increased significantly,the expression of bax mRNA and protein was increased significantly,while c-myc,bcl-2 mRNA and proteins were decreased markedly in combined agents group,compared with cisplatin group,the difference was statistically significant(P0.05 or P0.01).Conclusion Matrine injection combined with cisplatin can obviously induce apoptosis of SMMC-7721 cells with simple addition or synergistic effects,and its mechanism may be involved in up-regulating expression of bax gene and down-regulating expression of c-myc and bcl-2 genes." @default.
- W2352885292 created "2016-06-24" @default.
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- W2352885292 date "2012-01-01" @default.
- W2352885292 modified "2023-09-28" @default.
- W2352885292 title "Influence of matrine injection combined with cisplatin on the expression of apoptosis associated genes c-myc,bcl-2 and bax in human hepatocarcinoma cell line SMMC-7721" @default.
- W2352885292 hasPublicationYear "2012" @default.
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