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- W2352901039 abstract "Objective To investigate the relationship between Helicobacter pylori(H.pylori) infection and the histological changes of gastric mucosa in patients at scarring stage of duodenal ulcer(DU) to provide evidence to guide the therapy of this stage of ulceration.Methods Gastric biopsy specimens were obtained from 865 cases of duodenal ulcer patients,including 30 cases of active(A) ulcer,258 cases of healing(H) ulcer,and 577 cases of scarring(S) ulcer,diagnosed with endoscopic examination.The activity of gastric inflammation and the statue of H.pylori infection were evaluated by histological assays.Moreover,578 patients who were treated with proton pump inhibitor(PPI) in combination with two antibiotics for 1 week were followed up.Results The prevalence of H.pylori infection in patients with S stage of DU was 56.8%,which was lower than that of patients at stage A and stage H.65% of them were complicated with active inflammation in gastric mucosa.The response of patients at different stages of DU to anti-bacterial therapy was the same.29.8% of S stage of DU patients were still H.pylori positive after eradication treatment with 7.5% of them progressed into active stage.The incidence of gastric atrophy was higher in patients at stage A than those at stage H or stage S,whereas no difference was found among the three stage of lesions with regard to the incidence of intestinal metaplasia.Conclusion Stage S of DU diagnosed by gastroscopy was not truly cured,and further therapy to eradicate H.pylori remains to be necessary." @default.
- W2352901039 created "2016-06-24" @default.
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- W2352901039 date "2006-01-01" @default.
- W2352901039 modified "2023-09-26" @default.
- W2352901039 title "A study on the relationship among scarring stage of duodenal ulcer,gastric inflammation and Helicobacter pylori infection" @default.
- W2352901039 hasPublicationYear "2006" @default.
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