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- W2352912951 abstract "Objective To establish a simple and sensitive high performance liquid chromatography tandem mass spectrometry(HPLC-MS/MS) method for determination of terazosin in human plasma. Methods The plasma samples were precipitated with the liqui=d extraction by tert-butyl ether and then were injected directly into the HPLC–MS/MS system.Inertsil C18 column(2.1 mm×150 mm,3.0 μm) was used,and methanol-2 mmol·L-1ammonium acetate(90:10) was taken as the mobile phase by gradient elution.Terazosin and the internal standard(prazosin) were separated by HPLC and quantitated by MS/MS by using electrospray ionization(ESI) and multiple reaction monitoring(MRM) in the positive ion mode.The most intense + MRM transition of terazosin at m/z 388.4μm/z→m/z247.4 was used for quantitation,and the transition at m/z 384.2μm/z→m/z231.3 was used to monitor prazosin. Results The liner range of terazosin was 0.2-50 ng·mL-1(r= 0.9973),while the minimal detectable plasma concentration was 0.2 ng·mL-1.The average recovery was between 98.83% and 100.67%.Intra-day and inter-day RSD were less than 15%.Low,medium and high absolute recoveries were 75.40%,70.28%,67.39%,in line with biological sample analysis requirements. Conclusion This method is simple,sensitive and accurate,which is suitable for the study of pharmacokinetics of terazosin in human plasma and urine." @default.
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- W2352912951 date "2011-01-01" @default.
- W2352912951 modified "2023-09-22" @default.
- W2352912951 title "HPLC-MS/MS Determination of Terazosin in Human Plasma" @default.
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