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- W2352917363 abstract "Objective To investigate the effect on brain edema induced by thrombin and anti-edema by hirudin. Methods 80 healthy Wistar rats were randomly distributed to 4 groups(20 rats each group), and every group was divided two subgroups(on the third day and seventh day respectively) :Group A:infused saline plus saline; Group B: saline plus hirudin; Group C: self-body-blood plus saline; Group D: self-body-blood plus hirudin. Needles were inserted into the right caudate nuclears using stereo tactic guidance. Fifty microliters of self-body-nonhep-arinized-fresh blood(group C and D) or saline(group A and B) were infused in 10-15 minutes and detained for 20 minutes until needle was removed. At the second infusion, 10μl saline was infused into group A and C using the same coordinate and equivalent hirudin solution(concentration 2U/μl) was infused into group C and D. The rats which were measured the content of brain water were sacrificed by decapitation at the third and seventh day after the operation. Results Brain edema aggravated with intracerebral hemorrhage and hirudin could reduce brain edema(P0. 05). Conclusion Thrombin can lead to brain edema after cerebral hemorrhage which can be restrained by Hirudin. And then,hirudin doesn't produce any negative effect on brain tissue." @default.
- W2352917363 created "2016-06-24" @default.
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- W2352917363 date "2005-01-01" @default.
- W2352917363 modified "2023-09-25" @default.
- W2352917363 title "Mechanism of hirudin in brain edema after intracerebral hemorrhage" @default.
- W2352917363 hasPublicationYear "2005" @default.
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