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- W2352930714 abstract "Objective To observe the effects of low-dose atorvastatin in combination with aspirin on carotid atherosclerotic plaques,platelets surface P-selectin(CD62P),platelet glycoproteinⅡb/Ⅲa receptor complex(PAC-1),and high sensitivity C-reactive protein(hs-CRP) in patients with cerebral infarction.Methods A total 104 patients with acute cerebral infarction whose carotid atherosclerotic plaques were confirmed by ultrasonography were randomly assigned into three groups:the intervention group 1(n=34),intervention group 2(n=32) and the control group(n=38).Patients in intervention groups 1 and group 2 received oral atorvastatin 10 and 20 mg/d separately,and also received Bayaspirin 100 mg/d at the same time,while the control group only received Bayaspirin 100 mg/d.The plasma CD62P,PAC-1 and hs-CRP were detected 3 weeks after treatment;and the changes of carotid atherosclerotic plaques and lipid were examined with ultrasonography at 6 months.Results As compared between the 2 intervention groups,and the control group:①There was no significant difference in the size of carotid atherosclerotic plaques.②Before treatment,the numbers of unstable plaque in the 3 groups were 54,46 and 49,and the numbers of stable plaque were 5,6 and 4 respectively.After treatment,the numbers of unstable plaque were 44,34 and 50,and the numbers of stable plaque were 15,17 and 5 respectively.As compared with themselves and the control group before treatment,there were significant differences in both intervention groups.There were no significant differences before and after treatment in the control group and between the two intervention groups.③After treatment,the CD62P,PAC-1,and hs-CRP in the 2 intervention groups were reduced significantly than themselves before treatment and the control group(P0.01).④After treatment,the mean lipid levels in the two intervention groups were reduced(P0.01).There were 2 and 1 patients with total cholesterol 4.0 mmol/L in the intervention groups 1 and 2 before treatment,and there were 7 and 14 patients after treatment(P0.05).The changes of all the indices in the control group did not have statistical difference.⑤After treatment,the acute cerebrovascular events in the control group were 3 cases,in the intervention group 1 was 1 case,and in the intervention group 2 was 0 case.There were 6 patients(18.8%) experienced adverse drug reaction in the intervention group 2,while there was only 1(2.9%) in the intervention group 1.There was significant difference between the two groups(P0.05).Conclusion Atorvastatin in combination with aspirin inhibits platelet activation and inflammatory response.It has a certain effect on the stability of carotid atherosclerotic plaques.Aspirin in combination with atorvastatin 10 mg/d is more safe than 20 mg/d." @default.
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- W2352930714 date "2009-01-01" @default.
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- W2352930714 title "Effects of low-dose atorvastatin in combination with aspirin on carotid atherosclerotic plaques and blood biochemical parameters in patients with cerebral infarction" @default.
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