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- W2352936438 abstract "Objective To study the role of oxidative invasion and apoptosis during the acute renal ischemic reperfusion injury in the mechanism of kidney injury. Methods The model of acute renal ischemic reperfusion injury was established by methods of resecting the left kidney of rat and blocking the right kidney pedicle in the same time, glutathione peroxidase (GSH-Px) as well as superoxide dismutase (SOD) activity and malonical aldehyde (MDA) content were measured and renal apoptotic rate was determined.Results Renal SOD activity reduced and MDA content increased significantly in different periods of acute renal ischemic reperfusion injury compared to those of control group (P0.01 and P0.05, respectively); GSH-Px activity reduced in earlier injury period than that of controls (P0.01), but recovered in late period. There was significant difference in kidney apoptosis rate between injury group and control group (P0.01); there was negative correlation between SOD activity and apoptosis, and positive correlation between MDA content and apoptosis.Conclusions Oxidative invasion during different period of acute renal ischemic reperfusion injury could play an important role in renal injury and ischemic reperfusion injury has some correlation with oxidative invasion and apoptosis." @default.
- W2352936438 created "2016-06-24" @default.
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- W2352936438 date "2005-01-01" @default.
- W2352936438 modified "2023-09-25" @default.
- W2352936438 title "Oxidative invasion and apoptosis during acute renal ischemic reperfusion injury" @default.
- W2352936438 hasPublicationYear "2005" @default.
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