Matches in SemOpenAlex for { <https://semopenalex.org/work/W2352945377> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2352945377 abstract "Extensive studies have been performed on function of PD-1 in immunological regulation, while as so far, studies on the exact regulation mechanism of PD-1 expression have not been reported. PD-1 expression in EL4 and Sp2/0-Ag cell lines was detected with PE-Anti Mouse-PD-1 antibody through FACS. Genomic DNA from C57BL/6J mouse was used to produce different lengths of PD-1 promoter fragments. The PCR products were cloned into the luciferase reporter vector pGL3-Basic and co-transfected with pRL-SV40 into EL4 and Sp2/0-Ag cell lines to investigate the PD-1 promoter activity. FACS results showed that EL4 cells express PD-1 protein constituently, while Sp2/0-Ag cells express high level of PD-1 after stimulation with phorbol 12-myristate 13-acetate (PMA) plus ionomycin (IO). Luciferase assays revealed that the activity of different lengths of PD-1 promoter region was very alterable. This staggering negative-positive-negative arrangement indicates the complex regulation of PD-1 expression and provides important clues for elucidating the mechanisms of the PD-1 gene transcriptional regulation." @default.
- W2352945377 created "2016-06-24" @default.
- W2352945377 creator A5055161733 @default.
- W2352945377 date "2010-01-01" @default.
- W2352945377 modified "2023-09-28" @default.
- W2352945377 title "Identification and Characterization of The Promoter and Upstream Regulation Region of Mouse PD-1" @default.
- W2352945377 hasPublicationYear "2010" @default.
- W2352945377 type Work @default.
- W2352945377 sameAs 2352945377 @default.
- W2352945377 citedByCount "0" @default.
- W2352945377 crossrefType "journal-article" @default.
- W2352945377 hasAuthorship W2352945377A5055161733 @default.
- W2352945377 hasConcept C101762097 @default.
- W2352945377 hasConcept C104317684 @default.
- W2352945377 hasConcept C111335760 @default.
- W2352945377 hasConcept C150194340 @default.
- W2352945377 hasConcept C153911025 @default.
- W2352945377 hasConcept C161733203 @default.
- W2352945377 hasConcept C165864922 @default.
- W2352945377 hasConcept C185592680 @default.
- W2352945377 hasConcept C195794163 @default.
- W2352945377 hasConcept C202751555 @default.
- W2352945377 hasConcept C27153228 @default.
- W2352945377 hasConcept C2776989580 @default.
- W2352945377 hasConcept C2780043322 @default.
- W2352945377 hasConcept C54009773 @default.
- W2352945377 hasConcept C54355233 @default.
- W2352945377 hasConcept C62478195 @default.
- W2352945377 hasConcept C81885089 @default.
- W2352945377 hasConcept C86803240 @default.
- W2352945377 hasConcept C95444343 @default.
- W2352945377 hasConceptScore W2352945377C101762097 @default.
- W2352945377 hasConceptScore W2352945377C104317684 @default.
- W2352945377 hasConceptScore W2352945377C111335760 @default.
- W2352945377 hasConceptScore W2352945377C150194340 @default.
- W2352945377 hasConceptScore W2352945377C153911025 @default.
- W2352945377 hasConceptScore W2352945377C161733203 @default.
- W2352945377 hasConceptScore W2352945377C165864922 @default.
- W2352945377 hasConceptScore W2352945377C185592680 @default.
- W2352945377 hasConceptScore W2352945377C195794163 @default.
- W2352945377 hasConceptScore W2352945377C202751555 @default.
- W2352945377 hasConceptScore W2352945377C27153228 @default.
- W2352945377 hasConceptScore W2352945377C2776989580 @default.
- W2352945377 hasConceptScore W2352945377C2780043322 @default.
- W2352945377 hasConceptScore W2352945377C54009773 @default.
- W2352945377 hasConceptScore W2352945377C54355233 @default.
- W2352945377 hasConceptScore W2352945377C62478195 @default.
- W2352945377 hasConceptScore W2352945377C81885089 @default.
- W2352945377 hasConceptScore W2352945377C86803240 @default.
- W2352945377 hasConceptScore W2352945377C95444343 @default.
- W2352945377 hasOpenAccess W2352945377 @default.
- W2352945377 hasRelatedWork W1488327712 @default.
- W2352945377 hasRelatedWork W1567953207 @default.
- W2352945377 hasRelatedWork W1664785975 @default.
- W2352945377 hasRelatedWork W1927608037 @default.
- W2352945377 hasRelatedWork W1964864779 @default.
- W2352945377 hasRelatedWork W1978332591 @default.
- W2352945377 hasRelatedWork W2001340411 @default.
- W2352945377 hasRelatedWork W2043847594 @default.
- W2352945377 hasRelatedWork W2046469516 @default.
- W2352945377 hasRelatedWork W2052266897 @default.
- W2352945377 hasRelatedWork W2053801949 @default.
- W2352945377 hasRelatedWork W2073646238 @default.
- W2352945377 hasRelatedWork W2086273203 @default.
- W2352945377 hasRelatedWork W2141190704 @default.
- W2352945377 hasRelatedWork W2342861278 @default.
- W2352945377 hasRelatedWork W2358535682 @default.
- W2352945377 hasRelatedWork W2383764201 @default.
- W2352945377 hasRelatedWork W2402594941 @default.
- W2352945377 hasRelatedWork W2554827298 @default.
- W2352945377 hasRelatedWork W3029192458 @default.
- W2352945377 isParatext "false" @default.
- W2352945377 isRetracted "false" @default.
- W2352945377 magId "2352945377" @default.
- W2352945377 workType "article" @default.