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- W2352946095 abstract "Objective:To investigate the effect of probucol on the serum lipid,mast cells and atherosclerosis of New Zealand rabbits with normal diet or high fat/high cholesterol diet.Methods:Forty male New Zealand rabbits were respectively supplied with normal fodder,normal fodder and probucol,high fat /high cholesterol fodder,high fat /high cholesterol fodder and probucol for 4 weeks.The serum lipids were measured by the enzymatic colorimetric method.Mast cells were detected by toluidine blue staining.The aorta atherosclerotic lesion area was measured with Sudan Ⅳ staining.Results:Compared with high fat /high cholesterol fodder group,there were significantly decreased serum levels of triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C)(P 0.05),and also significantly decreased percentage of degranulated mast cells in aorta and in jejunum(P 0.001) and decreased aorta atherosclerotic lesion area(P 0.001) in high fat /high cholesterol fodder and probucol group.Conclusion:Probucol can decrease serum levels of TG,TC,LDL-C and HDL-C,and decrease the percentage of degranulated mast cells in aorta and in jejunum,and also the aorta atherosclerotic lesion area in New Zealand rabbits with high fat /high cholesterol diet." @default.
- W2352946095 created "2016-06-24" @default.
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- W2352946095 date "2012-01-01" @default.
- W2352946095 modified "2023-09-26" @default.
- W2352946095 title "Effect of Probucol on Atherosclerosis of New Zealand Rabbits" @default.
- W2352946095 hasPublicationYear "2012" @default.
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