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- W2352946190 abstract "Objective To compare the effects of antipsychotics on glucose and lipid metabolism and body weight of patients with first-episode schizophrenia,and to evaluate the safety of antipsychotics. Methods To follow-up the patients with first-episode schizophrenia for 1 year periodically, comparing the varies of fasting plasma glucose(FVPG),BMI and blood-lipid of patients taking atypical antipsychotic drugs (risperidone,quetiapine,aripiprazole) and typical anti psychotic drug (chlorpromazine). Results 179 patients were followed-up for 1 year, 22 patients had higher FVPG(12.3%)exceeding the range,1 patient was diagnosed diabetes; 48 patients(26.8%) had high TG level and 31 had high blood cholesterol level. Single factor correlating analysis showed exceeding range of FVPG had significant correlation with BMI,age,the course of disease and high TG,while having no significant correlation with choices of medication. All the antipsychotics affected glucose and lipid metabolism,aripiprazole had the least effect on body weight,blood glucose and blood lipid .Logistic regression analysis showed the increasing of BMI and longer course of disease were the risk factors of exceeding range of blood glucose.Conclusion Antipsychotics have influence on the glucose and lipid metabolism and body weight of patients with schizophrenia,which should be evaluated earlier,measured periodically and interfered as soon as possible." @default.
- W2352946190 created "2016-06-24" @default.
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- W2352946190 date "2009-01-01" @default.
- W2352946190 modified "2023-09-25" @default.
- W2352946190 title "Effects of antipsychotics on glucose and lipid metabolism and body weight of patients with first-episode schizophrenia" @default.
- W2352946190 hasPublicationYear "2009" @default.
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